| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
WNK1 |
| Specificity: |
This antibody reacts specifically with WNK1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human WNK1 |
| Gene ID: |
65125 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
SLC12A3, WNK1 may also play a role in actin cytoskeletal reorganization, WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, by phosphorylation, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1, WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HSAN2 PPP1R167 |
| Also known as: |
WNK1 Polyclonal Antibody |
| Other name: |
Anti-WNK1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
WNK1 |
| Short name: |
Anti-WNK1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-WNK lysine deficient protein kinase 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, WNK1 and IDBG-11521 and ENSG00000060237 and 65125, WNK1 and IDBG-641017 and ENSBTAG00000005221 and 506433, Wnk1 and IDBG-183036 and ENSMUSG00000045962 and 232341, this GO :0003084 and positive regulation of systemic arterial blood pressure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006811 and ion transport and biological process this GO :0010923 and negative regulation of phosphatase activity and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004860 : protein kinase inhibitor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019869 : chloride channel inhibitor activity, this GO :0019902 : phosphatase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869 : chloride channel inhibitor activity and also this GO :0019902 : phosphatase binding, transferring phosphorus-containing groups and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0019902 and phosphatase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0048666 and neuron development and biological process this GO :0050794 and regulation of cellular process and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process, WNK lysine deficient protein kinase 1 |
| Identity: |
14540 |
| Gene: |
WNK1 |
More about : WNK1 |
| Long gene name: |
WNK lysine deficient protein kinase 1 |
| Synonyms gene: |
PRKWNK1 HSN2 |
| Synonyms gene name: |
lysine deficient 1 hereditary sensory neuropathy, protein kinase, type II |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 167 |
| Locus: |
12p13, 33 |
| Discovery year: |
2001-02-06 |
| GenBank acession: |
AJ296290 |
| Entrez gene record: |
65125 |
| RefSeq identity: |
NM_018979 |
| Classification: |
Minor histocompatibility antigens Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000090321 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_247 |