| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Cystatin C/CST3 |
| Specificity: |
This antibody reacts specifically with Cystatin C/CST3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse Cystatin 3 |
| Gene ID: |
1471 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A mutation in this gene has been associated with amyloid angiopathy, Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, Some of the members are active cysteine protease inhibitors, The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes, The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, There are three inhibitory families in the superfamily, This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, [provided by RefSeq], establishing its role in vascular disease, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens, where they appear to provide protective functions, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body, while others have lost or perhaps never acquired this inhibitory activity, The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Cystatin C/CST3 Polyclonal Antibody |
| Other name: |
Anti-Cystatin C/CST3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Cystatin C/CST3 |
| Short name: |
Anti-Cystatin C/CST3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Cystatin C/CST3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2475 |
| Gene: |
CST3 |
More about : CST3 |
| Long gene name: |
cystatin C |
| Synonyms gene name: |
cystatin C (amyloid angiopathy and cerebral hemorrhage) |
| Locus: |
20p11, 21 |
| Discovery year: |
1990-02-06 |
| Entrez gene record: |
1471 |
| Pubmed identfication: |
8486384 |
| RefSeq identity: |
NM_000099 |
| Classification: |
Cystatins, type 2 |
| Havana BLAST/BLAT: |
OTTHUMG00000032080 |