| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Pin1 |
| Specificity: |
This antibody reacts specifically with Pin1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Pin1 |
| Gene ID: |
5300 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding, Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau, Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration, Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain, Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease, Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds, Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation, Pin1 is a Peptidyl-prolyl isomerases (PPIase) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
dod |
| Also known as: |
Pin1 Polyclonal Antibody |
| Other name: |
Anti-Pin1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Pin1 |
| Short name: |
Anti-Pin1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, NIMA-interacting 1 (polyclonal), antibody to-peptidylprolyl cis/trans isomerase |
| Alternative technique: |
polyclonals |
| Identity: |
8988 |
| Gene: |
PIN1 |
More about : PIN1 |
| Long gene name: |
NIMA-interacting 1 , peptidylprolyl cis/trans isomerase |
| Synonyms gene name: |
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 |
| Locus: |
19p13 |
| Discovery year: |
1996-12-16 |
| Entrez gene record: |
5300 |
| Pubmed identfication: |
8606777 |
| Classification: |
Parvulins |
| Havana BLAST/BLAT: |
OTTHUMG00000180388 |
| Locus Specific Databases: |
LRG_847 |