| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HIRA |
| Specificity: |
This antibody reacts specifically with HIRA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HIRA/DGGR1 |
| Gene ID: |
7290 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, Orthologs of this gene in flies, These foci likely mediate the irreversible cell cycle changes that occur in senescent cells, This gene plays an important role in the formation of the senescence-associated heterochromatin foci, and insufficient production of the gene may disrupt normal embryonic development, yeast and plants are necessary for the formation of transcriptionally silent heterochomatin, 3 in nucleosomes, The HIRA gene encodes a histone chaperone that preferentially places the variant histone H3 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DGCR1 TUP1 |
| Also known as: |
HIRA Polyclonal Antibody |
| Other name: |
Anti-HIRA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HIRA |
| Short name: |
Anti-HIRA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HIRA (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4916 |
| Gene: |
HIRA |
More about : HIRA |
| Long gene name: |
histone cell cycle regulator |
| Synonyms gene: |
TUPLE1 |
| Synonyms gene name: |
HIR (histone cell cycle regulation defective) homolog A (S, cerevisiae) , cerevisiae) HIR histone cell cycle regulation defective homolog A (S |
| Synonyms name: |
DiGeorge critical region gene 1 |
| Locus: |
22q11, 21 |
| Discovery year: |
1994-04-21 |
| GenBank acession: |
X75296 |
| Entrez gene record: |
7290 |
| Pubmed identfication: |
8111380 7633437 9731536 |
| RefSeq identity: |
NM_003325 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150134 |