| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SHIP1 Tyr1020 |
| Specificity: |
This antibody reacts specifically with SHIP1 (Tyr1020) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1020 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human SHIP1 around the phosphorylation site of Tyr1020 |
| Gene ID: |
3635 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
At the plasma membrane, Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation, Overall the protein functions as a negative regulator of myeliod cell proliferation and survival, an inositol phosphatase domain, and two C-terminal protein interaction domains, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, thereby affecting multiple signaling pathways, 3, 4, 4, 5)-trisphosphate and inositol-1, 5-tetrakisphosphate, SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SHIP hp51CN SHIP1 |
| Also known as: |
SHIP1 (Tyr1020) Polyclonal Antibody |
| Other name: |
Anti-SHIP1 (Tyr1020) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SHIP1 (Tyr1020) |
| Short name: |
Anti-SHIP1 (Tyr1020) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SHIP1 (Tyr1020) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6079 |
| Gene: |
INPP5D |
More about : INPP5D |
| Long gene name: |
inositol polyphosphate-5-phosphatase D |
| Synonyms gene name: |
145kD inositol polyphosphate-5-phosphatase, 145kDa , inositol polyphosphate-5-phosphatase |
| Synonyms name: |
SH2 domain-containing inositol 5', -phosphatase 1 |
| Locus: |
2q37, 1 |
| Discovery year: |
1996-04-04 |
| GenBank acession: |
U57650 |
| Entrez gene record: |
3635 |
| Pubmed identfication: |
8643691 8874179 |
| RefSeq identity: |
NM_001017915 |
| Classification: |
Phosphoinositide phosphatases SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000133688 |