| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RCC1 Ser11 |
| Specificity: |
This antibody reacts specifically with RCC1 (Ser11) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser11 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human RCC1 around the phosphorylation site of Ser11 |
| Gene ID: |
1104 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
RCC1, RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin, and, but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, to increase the affinity of chromatin for NE membranes, where bound, with chromatin , Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
RCC1 (Ser11) Polyclonal Antibody |
| Other name: |
Anti-RCC1 (Ser11) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RCC1 (Ser11) |
| Short name: |
Anti-RCC1 (Ser11) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RCC1 (Ser11) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1913 |
| Gene: |
RCC1 |
More about : RCC1 |
| Long gene name: |
regulator of chromosome condensation 1 |
| Synonyms gene: |
CHC1 |
| Synonyms gene name: |
chromosome condensation 1 |
| Locus: |
1p35, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
X12654 |
| Entrez gene record: |
1104 |
| Pubmed identfication: |
7851910 |
| RefSeq identity: |
NM_001269 |
| Havana BLAST/BLAT: |
OTTHUMG00000003645 |