| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Met c-Met Tyr1003 |
| Specificity: |
This antibody reacts specifically with Met (c-Met) (Tyr1003) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1003 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human c-Met around the phosphorylation site of Tyr1003 |
| Gene ID: |
4233 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
AKT, Cbl, Cells expressing c-Met include epithelial cells, Crk, ERK1 and 2, FAK, GAB1, HGF/SF stimulation of c-Met expressing cells enhances proliferation, In addition to cancer studies, JNK, Many types of cancer exhibit sustained c-Met stimulation, PI3K, PLC gamma, Ras, Shc, Signaling proteins that are phosphorylated and/or localized in response to c-Met phosphorylation include: Grb2, Src, The mature c-Met protein is a disulfide-linked heterodimer with Mr=190 kDa composed of a heavily glycosylated alpha subunit that is completely extracellular in localization, a member of the tyrosine kinase superfamily, a single transmembrane domain, also known as scatter factor (HGF/SF), and STAT3, and a beta subunit comprising an extracellular ligand binding domain, and a cytoplasmic tyrosine kinase domain, and glomerular mesenchymal cells, and protease synthesis, angiogenesis and surgical wound healing, as well as melanomas and sarcomas, blood cells of various types, breast, characteristics that are associated with invasive cell phenotype, cortactin, endothelial cells, including carcinomas of the colon, is the receptor for hepatocyte growth factor, kidney, liver, lung, migration, morphogenesis, or mutation, organ regeneration, other research areas in which c-Met is under investigation include organogenesis, ovary, overexpression, paxillin, prostate, thyroid, &euro, &trade, HGF/SF binding to c-Met stimulates receptor dimerization and the phosphorylation of numerous residues within the receptorâ, c-Met, s cytoplasmic domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AUTS9, D249, HGF, HGF SF receptor, HGF receptor, HGF/SF receptor, HGFR, Hepatocyte growth factor receptor, Hepatocyte growth factor receptor Precursor, MET, MET_HUMAN, Met proto oncogene tyrosine kinase, Met proto-oncogene, Met proto-oncogene hepatocyte growth factor receptor, Met protooncogene, Oncogene MET, Par4, Proto-oncogene c-Met, RCCP2, Renal cell carcinoma papillary 2 gene, SF receptor, Scatter factor receptor, Tyrosine-protein kinase Met, c met, cmet, Met c-Met Tyr1003 |
| Also known as: |
Met (c-Met) (Tyr1003) Antibody |
| Other name: |
Anti-Met (c-Met) (Tyr1003) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Met (c-Met) (Tyr1003) |
| Short name: |
Anti-Met (c-Met) (Tyr1003) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Met (c-Met) (Tyr1003) |