| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Lamin A/C Ser22 |
| Specificity: |
This antibody reacts specifically with Lamin A/C(Ser22) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser22 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human Lamin A/C around the phosphorylation site of Ser22 |
| Gene ID: |
4000 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A type lamins and B type lamins, In addition, Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, Two main subtypes of nuclear lamins can be distinguished, a role in the regulation of differential gene expression has been suggested for A type lamins, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy, i, i, i, including Emery-Dreifuss muscular dystrophy, lamin A, lamin B1 and lamin B2, lamin C and lamin Adel 10, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, while the B type lamins include two proteins arising from two distinct genes, Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane, e, e, e |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LAMIN A, LAMIN C, LDP1, LFP, LGMD1B, LMN 1, LMN A, LMN C, LMNA, LMNC, NY REN 32 antigen, PRO1, lamin A/C, LMN1 |
| Also known as: |
Lamin A/C(Ser22) Polyclonal Antibody |
| Other name: |
Anti-Lamin A/C(Ser22) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Lamin A/C(Ser22) |
| Short name: |
Anti-Lamin A/C(Ser22) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Lamin A/C(Ser22) (polyclonal) |
| Alternative technique: |
polyclonals |