| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
LRP6 Ser1490 |
| Specificity: |
This antibody reacts specifically with LRP6 (Ser1490) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser1490 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490 |
| Gene ID: |
4040 |
| Swiss Prot: |
O75581 |
| Applications: |
IF(ICC), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Cell-surface coreceptor of Wnt/beta-catenin signaling, Required for posterior patterning of the epiblast during gastrulation (By similarity), The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, which plays a pivotal role in bone formation, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ADCAD2 |
| Also known as: |
LRP6 (Ser1490) Polyclonal Antibody |
| Other name: |
Anti-LRP6 (Ser1490) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
LRP6 (Ser1490) |
| Short name: |
Anti-LRP6 (Ser1490) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-low density lipoprotein receptor-related protein 6 (Ser1490) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ADCAD2, Cell surfaces, DNA-templated and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007268 and synaptic transmission and biological process this GO :0009880 and embryonic pattern specification and biological process this GO :0009950 and dorsal/ventral axis specification and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009986 and cell surface and cellular component this GO :0014029 and neural crest formation and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0019210 and kinase inhibitor activity and molecular function this GO :0019534 and toxin transporter activity and molecular function this GO :0021587 and cerebellum morphogenesis and biological process this GO :0021794 and thalamus development and biological process this GO :0021795 and cerebral cortex cell migration and biological process this GO :0021861 and forebrain radial glial cell differentiation and biological process this GO :0021872 and forebrain generation of neurons and biological process this GO :0021874 and Wnt receptor signaling pathway involved in forebrain neuroblast division and biological process this GO :0021915 and neural tube development and biological process this GO :0021943 and formation of radial glial scaffolds and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030278 and regulation of ossification and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030900 and forebrain development and biological process this GO :0030901 and midbrain development and biological process this GO :0030917 and midbrain-hindbrain boundary development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0034185 and apolipoprotein binding and molecular function this GO :0034392 and negative regulation of smooth muscle cell apoptotic process and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035115 and embryonic forelimb morphogenesis and biological process this GO :0035116 and embryonic hindlimb morphogenesis and biological process this GO :0035261 and external genitalia morphogenesis and biological process this GO :0036342 and post-anal tail morphogenesis and biological process this GO :0042074 and cell migration involved in gastrulation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0044332 and Wnt signaling pathway involved in dorsal/ventral axis specification and biological process this GO :0044335 and canonical Wnt receptor signaling pathway involved in neural crest cell differentiation and biological process this GO :0044340 and canonical Wnt signaling pathway involved in regulation of cell proliferation and biological process this GO :0045202 and synapse and cellular component this GO :0045598 and regulation of fat cell differentiation and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045778 and positive regulation of ossification and biological process this GO :0045780 and positive regulation of bone resorption and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0048699 and generation of neurons and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051593 and response to folic acid and biological process this GO :0060021 and palate development and biological process this GO :0060026 and convergent extension and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060284 and regulation of cell development and biological process this GO :0060325 and face morphogenesis and biological process this GO :0060349 and bone morphogenesis and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0060535 and trachea cartilage morphogenesis and biological process this GO :0060596 and mammary placode formation and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0061310 and canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development and biological process this GO :0061324 and canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation and biological process this GO :0071397 and cellular response to cholesterol and biological process this GO :0071542 and dopaminergic neuron differentiation and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0071936 and coreceptor activity involved in Wnt receptor signaling pathway and molecular function this GO :0090009 and primitive streak formation and biological process this GO :0090118 and receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport and biological process this GO :0090244 and Wnt signaling pathway involved in somitogenesis and biological process this GO :0090245 and axis elongation involved in somitogenesis and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1901998 and toxin transport and biological process this GO :2000051 and negative regulation of non-canonical Wnt signaling pathway and biological process this GO :2000055 and positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification and biological process this GO :2000149 and negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis and biological process this GO :2000151 and negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis and biological process this GO :2000162 and negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis and biological process this GO :2000164 and negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis and biological process this GO :2000166 and negative regulation of planar cell polarity pathway involved in pericardium morphogenesis and biological process this GO :2000168 and negative regulation of planar cell polarity pathway involved in neural tube closure and biological process, LRP6 and IDBG-20075 and ENSG00000070018 and 4040, LRP6 and IDBG-639434 and ENSBTAG00000011761 and 536328, Lrp6 and IDBG-194033 and ENSMUSG00000030201 and 102642234, coreceptor activity involved in Wnt receptor signaling pathway, this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001756 and somitogenesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001947 and heart looping and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003344 and pericardium morphogenesis and biological process this GO :0003401 and axis elongation and biological process this GO :0005041 and low-density lipoprotein receptor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005109 and frizzled binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005769 and early endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006355 and regulation of transcription, this GO :0005041 : low-density lipoprotein receptor activity, this GO :0005041 : low-density lipoprotein receptor activity and also this GO :0005102 : receptor binding and also this GO :0005109 : frizzled binding and also this GO :0005515 : protein binding and also this GO :0017147 : Wnt-protein binding and also this GO :0019210 : kinase inhibitor activity and also this GO :0019534 : toxin transporter activity and also this GO :0034185 : apolipoprotein binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0042813 : Wnt-activated receptor activity and also this GO :0071936 : coreceptor activity involved in Wnt receptor signaling pathway, this GO :0005102 : receptor binding, this GO :0005109 : frizzled binding, this GO :0005515 : protein binding, this GO :0017147 : Wnt-protein binding, this GO :0019210 : kinase inhibitor activity, this GO :0019534 : toxin transporter activity, this GO :0034185 : apolipoprotein binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0042813 : Wnt-activated receptor activity, this GO :0071936 : coreceptor activity involved in Wnt receptor signaling pathway, 16974, low density lipoprotein receptor-related protein 6 |
| Identity: |
6698 |
| Gene: |
LRP6 |
More about : LRP6 |
| Long gene name: |
LDL receptor related protein 6 |
| Synonyms gene name: |
low density lipoprotein receptor-related protein 6 |
| Locus: |
12p13, 2 |
| Discovery year: |
1998-04-07 |
| GenBank acession: |
AF074264 |
| Entrez gene record: |
4040 |
| Pubmed identfication: |
9704021 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000168540 |