| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DOK2 Tyr351 |
| Specificity: |
Due to the highly conserved nature of this sequence with DOK1, this antibody may react with DOK1 when it is phosphorylated at Tyr362 in Human and Tyr361 in Mouse and Rat, DOK2 (Tyr351), This phosphorylation site is found at Tyr345 in Human |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr351 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from mouse p56Dok2 around the phosphorylation site of (Tyr351) |
| Gene ID: |
13449 |
| Swiss Prot: |
O70469 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Attenuates EGF-stimulated MAP kinase activation, DOK2 may modulate the cellular proliferation induced by IL-4, May be involved in modulating Bcr-Abl signaling, They provide a docking platform for the assembly of multimolecular signaling complexes, as well as IL-2 and IL-3, DOK proteins are enzymatically inert adaptor or scaffolding proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
p56dok-2 Dok-2 |
| Also known as: |
DOK2 (Tyr351) Polyclonal Antibody |
| Other name: |
Anti-DOK2 (Tyr351) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DOK2 (Tyr351) |
| Short name: |
Anti-DOK2 (Tyr351) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-DOK2 (Tyr351) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2991 |
| Gene: |
DOK2 |
More about : DOK2 |
| Long gene name: |
docking protein 2 |
| Synonyms gene name: |
56kD docking protein 2, 56kDa , docking protein 2 |
| Synonyms name: |
downstream of tyrosine kinase 2 |
| Locus: |
8p21, 3 |
| Discovery year: |
1999-02-05 |
| GenBank acession: |
AF034970 |
| Entrez gene record: |
9046 |
| Pubmed identfication: |
9478921 14645010 |
| RefSeq identity: |
NM_003974 |
| Havana BLAST/BLAT: |
OTTHUMG00000131075 |