| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CSF1R Tyr723 |
| Specificity: |
This antibody reacts specifically with CSF1R (Tyr723) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr723 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 723 |
| Gene ID: |
1436 |
| Swiss Prot: |
P07333 |
| Applications: |
IF(ICC), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Dog, Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CD115 is expressed by cells of the monocytic lineage and by progenitor cells, Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation, Mutations in this gene have been associated with a predisposition to myeloid malignancy, The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains, This receptor mediates most if not all of the biological effects of this cytokine, a cytokine which controls the production, and function of macrophages, differentiation, This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
C-FMS CSFR CD115 |
| Also known as: |
CSF1R (Tyr723) Polyclonal Antibody |
| Other name: |
Anti-CSF1R (Tyr723) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CSF1R (Tyr723) |
| Short name: |
Anti-CSF1R (Tyr723) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-colony stimulating factor 1 receptor (Tyr723) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005011 and macrophage colony-stimulating factor receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005011 : macrophage colony-stimulating factor receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005011 : macrophage colony-stimulating factor receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019903 : protein phosphatase binding, this GO :0019955 : cytokine binding, this GO :0042803 : protein homodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019903 : protein phosphatase binding and also this GO :0019955 : cytokine binding and also this GO :0042803 : protein homodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0019955 and cytokine binding and molecular function this GO :0030097 and hemopoiesis and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031529 and ruffle organization and biological process this GO :0036006 and cellular response to macrophage colony-stimulating factor stimulus and biological process this GO :0038145 and macrophage colony-stimulating factor signaling pathway and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045217 and cell-cell junction maintenance and biological process this GO :0046488 and phosphatidylinositol metabolic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090197 and positive regulation of chemokine secretion and biological process this GO :2000147 and positive regulation of cell motility and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process, colony stimulating factor 1 receptor |
| Identity: |
2433 |
| Gene: |
CSF1R |
More about : CSF1R |
| Long gene name: |
colony stimulating factor 1 receptor |
| Synonyms gene: |
FMS |
| Synonyms gene name: |
McDonough feline sarcoma viral (v-fms) oncogene homolog |
| Locus: |
5q32 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
U63963 |
| Entrez gene record: |
1436 |
| Pubmed identfication: |
1611909 |
| RefSeq identity: |
NM_005211 |
| Classification: |
Immunoglobulin like domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130050 |