| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SQSTM1 |
| Specificity: |
This antibody reacts specifically with SQSTM1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62 |
| Gene ID: |
8878 |
| Swiss Prot: |
Q13501 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Adapter that mediates the interaction between TRAF6 and CYLD (By similarity), Involved in midbody ring degradation, May be involved in cell differentiation, May play a role in titin/TTN downstream signaling in muscle cells, May regulate signaling cascades through ubiquitination, May regulate the activation of NFKB1 by TNF-alpha, Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, apoptosis, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery, immune response and regulation of K(+) channels, nerve growth factor (NGF) and interleukin-1, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
p62 p60 p62B A170 |
| Also known as: |
SQSTM1 Polyclonal Antibody |
| Other name: |
Anti-SQSTM1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SQSTM1 |
| Short name: |
Anti-SQSTM1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-sequestosome 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
A170 and OSIL and p60 and p62 and p62B and PDB3 and ZIP3, BT, K63-linked polyubiquitin binding, SQSTM1 and IDBG-61811 and ENSG00000161011 and 8878, Sqstm1 and IDBG-168358 and ENSMUSG00000015837 and 18412, nuclei, this GO :0000407 and pre-autopha this GO somal structure and cellular component this GO :0000932 and cytoplasmic mRNA processing body and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002376 and immune system process and biological process this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006914 and autophagy and biological process this GO :0006950 and response to stress and biological process this GO :0008104 and protein localization and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016197 and endosomal transport and biological process this GO :0016234 and inclusion body and cellular component this GO :0016235 and aggresome and cellular component this GO :0016236 and macroautophagy and biological process this GO :0016239 and positive regulation of macroautophagy and biological process this GO :0016605 and PML body and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030154 and cell differentiation and biological process this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0035556 and intracellular signal transduction and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043122 and regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046578 and regulation of Ras protein signal transduction and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070530 and K63-linked polyubiquitin binding and molecular function this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004674 : protein serine/threonine kinase activity and also this GO :0005080 : protein kinase C binding and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0019901 : protein kinase binding and also this GO :0030971 : receptor tyrosine kinase binding and also this GO :0042169 : SH2 domain binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043130 : ubiquitin binding and also this GO :0070530 : K63-linked polyubiquitin binding, this GO :0005080 : protein kinase C binding, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0019901 : protein kinase binding, this GO :0030971 : receptor tyrosine kinase binding, this GO :0042169 : SH2 domain binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043130 : ubiquitin binding, this GO :0070530 : K63-linked polyubiquitin binding, 105440 and IDBG-640935 and ENSBTAG00000015591 and 338045, sequestosome 1 |
| Identity: |
11280 |
| Gene: |
SQSTM1 |
More about : SQSTM1 |
| Long gene name: |
sequestosome 1 |
| Synonyms gene: |
PDB3 OSIL |
| Synonyms gene name: |
Paget disease of bone 3 oxidative stress induced like |
| Locus: |
5q35, 3 |
| Discovery year: |
2000-06-13 |
| GenBank acession: |
U46751 |
| Entrez gene record: |
8878 |
| Pubmed identfication: |
8650207 8551575 |
| Classification: |
Zinc fingers ZZ-type |
| Havana BLAST/BLAT: |
OTTHUMG00000150643 |