| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IL-1R1 |
| Specificity: |
This antibody reacts specifically with IL1 Receptor I |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IL-1R1 |
| Gene ID: |
3554 |
| Swiss Prot: |
P14778 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex, IL1B and IL1RN, MAPK and other pathways, MYD88, Signaling involves the recruitment of adapter molecules such as TOLLIP, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, Receptor for IL1A |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IL1F1 IL-1A IL1-ALPHA |
| Also known as: |
IL1 Receptor I Polyclonal Antibody |
| Other name: |
Anti-IL1 Receptor I Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IL1 Receptor I |
| Short name: |
Anti-IL1 Receptor I (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-IL1 Receptor I (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
5991 |
| Gene: |
IL1A |
More about : IL1A |
| Long gene name: |
interleukin 1 alpha |
| Synonyms gene: |
IL1 |
| Synonyms name: |
preinterleukin 1 alpha hematopoietin-1 pro-interleukin-1-alpha |
| Locus: |
2q14, 1 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M28983 |
| Entrez gene record: |
3552 |
| Pubmed identfication: |
8188271 2989698 |
| RefSeq identity: |
NM_000575 |
| Classification: |
Endogenous ligands Interleukins |
| Havana BLAST/BLAT: |
OTTHUMG00000131315 |