| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
c-Ros |
| Specificity: |
This antibody reacts specifically with c-Ros |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human c-Ros |
| Gene ID: |
6098 |
| Swiss Prot: |
P08922 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
IRS1 and PLCG2, MAPK1, MAPK3, May activate other downstream signaling proteins including AKT1, May activate several downstream signaling pathways related to cell differentiation, May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth, Mediates the phosphorylation and the activation of VAV3, Mediates the phosphorylation of PTPN11, a guanine nucleotide exchange factor regulating cell morphology, an activator of this pathway, growth and survival including the PI3 kinase-mTOR signaling pathway, proliferation, Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MCF3 ROS c-ros-1 |
| Also known as: |
c-Ros Polyclonal Antibody |
| Other name: |
Anti-c-Ros Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
c-Ros |
| Short name: |
Anti-c-Ros (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-c-Ros (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10261 |
| Gene: |
ROS1 |
More about : ROS1 |
| Long gene name: |
ROS proto-oncogene 1, receptor tyrosine kinase |
| Synonyms gene name: |
receptor tyrosine kinase , v-ros avian UR2 sarcoma virus oncogene homolog 1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) c-ros oncogene 1 |
| Locus: |
6q22, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M13599 |
| Entrez gene record: |
6098 |
| Pubmed identfication: |
1611909 |
| Classification: |
Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016188 |
| Locus Specific Databases: |
LRG_997 |