| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Apelin |
| Specificity: |
This antibody reacts specifically with Apelin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Apelin |
| Gene ID: |
8862 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Apelin and APJ are ubiquitously expressed in peripheral tissues, In the cardiovascular system several actions of Apelin have been described, The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1, as well several regions within the central nervous system, by influencing AVP release and drinking behavior, including endothelium-dependent vasodilatation, more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates, vasoconstriction through direct action on smooth muscle and positive inotropism, with highest levels reported for heart and lungs, Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
apelin XNPEP2 |
| Also known as: |
Apelin Polyclonal Antibody |
| Other name: |
Anti-Apelin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Apelin |
| Short name: |
Anti-Apelin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Apelin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16665 |
| Gene: |
APLN |
More about : APLN |
| Long gene name: |
apelin |
| Synonyms gene name: |
AGTRL1 ligand , apelin |
| Locus: |
Xq26, 1 |
| Discovery year: |
2004-06-01 |
| GenBank acession: |
AF179680 |
| Entrez gene record: |
8862 |
| Pubmed identfication: |
9792798 10525157 |
| RefSeq identity: |
NM_017413 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000022371 |
| Locus Specific Databases: |
Mental Retardation database |