| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
p38 MAPK Thr180 + Tyr182 |
| Specificity: |
This antibody reacts specifically with p38 MAPK (Thr180 + Tyr182) |
| Modification: |
Phosphorylation |
| Modification site: |
Thr180 + Tyr182 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human p38 MAPK around the phosphorylation site of(Thr180/Tyr182) |
| Gene ID: |
1432 |
| Swiss Prot: |
Q16539 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Goat, Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, Jul 2008], MAP kinases act as an integration point for multiple biochemical signals, MEF2C, The activation requires its phosphorylation by MAP kinase kinases (MKKs), The substrates of this kinase include transcription regulator ATF2, This kinase is activated by various environmental stresses and proinflammatory cytokines, [provided by RefSeq, and MAX, and are involved in a wide variety of cellular processes such as proliferation, and tumor suppressor p53, as well as in genotoxic stress response, cell cycle regulator CDC25B, differentiation, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase, transcription regulation and development, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, The protein encoded by this gene is a member of the MAP kinase family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CSAID-binding protein, CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, EXIP, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAPK14, MAX-interacting protein 2, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, Mxi2, PRKM14, PRKM15, SAPK2A, Stress-activated protein kinase 2a, p38, p38ALPHA, RK |
| Also known as: |
p38 MAPK (Thr180 + Tyr182) Antibody |
| Other name: |
Anti-p38 MAPK (Thr180 + Tyr182) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
p38 MAPK (Thr180 + Tyr182) |
| Short name: |
Anti-p38 MAPK (Thr180 + Tyr182) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-p38 MAPK (Thr180 and Tyr182) |