| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MASP |
| Specificity: |
This antibody reacts specifically with MASP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MASP |
| Gene ID: |
5648 |
| Swiss Prot: |
P48740 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction, Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5, The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them, Functions in the lectin pathway of complement |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MASP |
| Also known as: |
MASP Polyclonal Antibody |
| Other name: |
Anti-MASP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MASP |
| Short name: |
Anti-MASP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MASP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6901 |
| Gene: |
MASP1 |
More about : MASP1 |
| Long gene name: |
mannan binding lectin serine peptidase 1 |
| Synonyms gene: |
CRARF PRSS5 |
| Synonyms gene name: |
mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor) mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| Synonyms name: |
C4/C2 activating component of Ra-reactive factor |
| Locus: |
3q27, 3 |
| Discovery year: |
1995-07-06 |
| GenBank acession: |
D28593 |
| Entrez gene record: |
5648 |
| Pubmed identfication: |
8018603 8240317 |
| RefSeq identity: |
NM_001879 |
| Classification: |
Sushi domain containing Proteases, serine |
| Havana BLAST/BLAT: |
OTTHUMG00000156461 |
| Locus Specific Databases: |
LRG_349 |