| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCL21/6Ckine |
| Specificity: |
This antibody reacts specifically with CCL21/6Ckine |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CCL21 |
| Gene ID: |
6366 |
| Swiss Prot: |
O00585 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4, Chemotactic in vitro for thymocytes and activated T-cells, May play a role in mediating homing of lymphocytes to secondary lymphoid organs, Shows preferential activity towards naive T-cells, but not for B-cells, macrophages, or neutrophils, Inhibits hemopoiesis and stimulates chemotaxis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SLC exodus-2 TCA4 CKb9 6Ckine ECL |
| Also known as: |
CCL21/6Ckine Polyclonal Antibody |
| Other name: |
Anti-CCL21/6Ckine Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCL21/6Ckine |
| Short name: |
Anti-CCL21/6Ckine (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-C motif) ligand 21/6Ckine (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
6Ckine and CKb9 and ECL and SCYA21 and SLC and TCA4, BT, CCL21 and IDBG-61074 and ENSG00000137077 and 6366, Extracellular, chemokine receptor binding, this GO :0001768 and establishment of T cell polarity and biological process this GO :0001771 and immunological synapse formation and biological process this GO :0001954 and positive regulation of cell-matrix adhesion and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0002606 and positive regulation of dendritic cell antigen processing and presentation and biological process this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008009 and chemokine activity and molecular function this GO :0010560 and positive regulation of glycoprotein biosynthetic process and biological process this GO :0030838 and positive regulation of actin filament polymerization and biological process this GO :0031274 and positive regulation of pseudopodium assembly and biological process this GO :0031295 and T cell costimulation and biological process this GO :0031529 and ruffle organization and biological process this GO :0031732 and CCR7 chemokine receptor binding and molecular function this GO :0032862 and activation of Rho GTPase activity and biological process this GO :0033630 and positive regulation of cell adhesion mediated by integrin and biological process this GO :0034695 and response to prostaglandin E and biological process this GO :0035759 and mesangial cell-matrix adhesion and biological process this GO :0042379 and chemokine receptor binding and molecular function this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0048260 and positive regulation of receptor-mediated endocytosis and biological process this GO :0048469 and cell maturation and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060326 and cell chemotaxis and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :0097026 and dendritic cell dendrite assembly and biological process this GO :2000107 and negative regulation of leukocyte apoptotic process and biological process this GO :2000147 and positive regulation of cell motility and biological process this GO :2000406 and positive regulation of T cell migration and biological process this GO :2000529 and positive regulation of myeloid dendritic cell chemotaxis and biological process this GO :2000548 and negative regulation of dendritic cell dendrite assembly and biological process, this GO :0008009 : chemokine activity, this GO :0008009 : chemokine activity and also this GO :0031732 : CCR7 chemokine receptor binding and also this GO :0042379 : chemokine receptor binding, this GO :0031732 : CCR7 chemokine receptor binding, this GO :0042379 : chemokine receptor binding, 26536 and IDBG-635977 and ENSBTAG00000010161 and 511112, chemokine (C-C motif) ligand 21 |
| Identity: |
10620 |
| Gene: |
CCL21 |
More about : CCL21 |
| Long gene name: |
C-C motif chemokine ligand 21 |
| Synonyms gene: |
SCYA21 |
| Synonyms gene name: |
member 21 chemokine (C-C motif) ligand 21 , small inducible cytokine subfamily A (Cys-Cys) |
| Synonyms name: |
beta chemokine exodus-2 secondary lymphoid tissue chemokine Efficient Chemoattractant for Lymphocytes |
| Locus: |
9p13, 3 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
AB002409 |
| Entrez gene record: |
6366 |
| Pubmed identfication: |
9235955 |
| RefSeq identity: |
NM_002989 |
| Classification: |
Endogenous ligands Chemokine ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000019838 |