| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ATP7A |
| Specificity: |
This antibody reacts specifically with ATP7A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ATP7A |
| Gene ID: |
538 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in ATP7A are the cause of Menkes syndrome, It may supply copper to copper-requiring proteins within the secretory pathway, Under conditions of elevated extracellular copper, also known as kinky hair disease, an X-linked recessive disorder, it relocalized to the plasma membrane where it functions in the efflux of copper from cells, when localized in the trans-golgi network, Copper-transporting ATPase 1 is an integral membrane protein cycling constitutively between the trans-golgi network and the plasma membrane |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
ATP7A Polyclonal Antibody |
| Other name: |
Anti-ATP7A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ATP7A |
| Short name: |
Anti-ATP7A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ATP7A (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
869 |
| Gene: |
ATP7A |
More about : ATP7A |
| Long gene name: |
ATPase copper transporting alpha |
| Synonyms gene: |
MNK |
| Synonyms gene name: |
Cu++ transporting, Menkes syndrome ATPase, alpha polypeptide |
| Synonyms name: |
copper pump 1 copper-transporting ATPase 1 |
| Locus: |
Xq21, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
L06133 |
| Entrez gene record: |
538 |
| Pubmed identfication: |
10079817 |
| RefSeq identity: |
NM_000052 |
| Classification: |
ATPase copper transporting |
| Havana BLAST/BLAT: |
OTTHUMG00000021885 |
| Locus Specific Databases: |
Mental Retardation database |