| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
JAK1 |
| Specificity: |
This antibody reacts specifically with JAK1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human JAK1 |
| Gene ID: |
3716 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is involved in the interferon-alpha/beta and -gamma signal transduction pathways, JAK1 is a large, The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, The second phosphotransferase domain bears all the hallmarks of a protein kinase, These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, although its structure differs significantly from that of the PTK and threonine/serine kinase family members, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes, or STATs, widely expressed membrane-associated phosphoprotein, Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
JAK1A JTK3 |
| Also known as: |
JAK1 Polyclonal Antibody |
| Other name: |
Anti-JAK1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
JAK1 |
| Short name: |
Anti-JAK1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Janus kinase 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
JAK1 and IDBG-638346 and ENSBTAG00000003147 and 537201, JAK1 and IDBG-99443 and ENSG00000162434 and 3716, JAK1A and JAK1B and JTK3, Jak1 and IDBG-167366 and ENSMUSG00000028530 and 16451, nuclei, this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005131 and growth hormone receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007167 and enzyme linked receptor protein signaling pathway and biological process this GO :0012505 and endomembrane system and cellular component this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005131 : growth hormone receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005131 : growth hormone receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019903 : protein phosphatase binding, this GO :0031730 : CCR5 chemokine receptor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019903 : protein phosphatase binding and also this GO :0031730 : CCR5 chemokine receptor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0031730 and CCR5 chemokine receptor binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0038110 and interleukin-2-mediated signaling pathway and biological process this GO :0045087 and innate immune response and biological process this GO :0046677 and response to antibiotic and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process, Janus kinase 1 |
| Identity: |
6190 |
| Gene: |
JAK1 |
More about : JAK1 |
| Long gene name: |
Janus kinase 1 |
| Synonyms gene: |
JAK1B |
| Locus: |
1p31, 3 |
| Discovery year: |
1992-04-16 |
| GenBank acession: |
M64174 |
| Entrez gene record: |
3716 |
| Pubmed identfication: |
1848670 7698020 |
| RefSeq identity: |
NM_002227 |
| Classification: |
FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000009310 |