| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Desmoglein 4 |
| Specificity: |
This antibody reacts specifically with Desmoglein 4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Desmoglein 4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
37% with human desmoglein 2 and 50% with human desmoglein 3, A type I membrane protein of the cadherin protein family, Desmoglein 4 (dsg4) shares 41% identity with human desmoglein 1, In the hair follicle, The human DSG4 gene is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3, dsg4 is an important mediator of keratinocyte cell adhesion and coordinates the transition from proliferation to differentiation, dsg4 is expressed in salivary gland, hair follicle, prostate and skin, suprabasal epidermis, testis, Desmoglein proteins are cadherin-type cell adhesion molecules |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CDHF13 LAH |
| Also known as: |
Desmoglein 4 Polyclonal Antibody |
| Other name: |
Anti-Desmoglein 4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Desmoglein 4 |
| Short name: |
Anti-Desmoglein 4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Desmoglein 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21307 |
| Gene: |
DSG4 |
More about : DSG4 |
| Long gene name: |
desmoglein 4 |
| Locus: |
18q12, 1 |
| Discovery year: |
2003-06-04 |
| GenBank acession: |
AY177664 AY168788 |
| Entrez gene record: |
147409 |
| Pubmed identfication: |
12648213 |
| RefSeq identity: |
NM_177986 |
| Classification: |
Desmosomal cadherins |
| Havana BLAST/BLAT: |
OTTHUMG00000131979 |