| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HSH2D |
| Specificity: |
This antibody reacts specifically with HSH2D |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HSH2D |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Considered an adaptor protein, Containing an SH2 domain, HSH2 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 19p13, HSH2 interacts with tyrosine kinases Fes and ACK, HSH2 may also act to attenuate apoptosis through modulating the apoptotic response by promoting mitochondrial stability, HSH2 participates in tyrosine kinase signaling and may be involved in the regulation of cytokine signaling and cytoskeletal reorganization in hematopoietic cells, and weakly expressed in prostate, four PXXP polyproline sequences and two possible tyrosine phosphorylation sites, heart, small intestine and placenta, such as peripheral blood leukocytes, thymus, 11, HSH2 is a 352 amino acid nuclear and cytoplasmic protein that is predominantly expressed in spleen and hematopoietic cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALX HSH2 FLJ14886 |
| Also known as: |
HSH2D Polyclonal Antibody |
| Other name: |
Anti-HSH2D Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HSH2D |
| Short name: |
Anti-HSH2D (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-hematopoietic SH2 domain containing (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
HSH2D and IDBG-35350 and ENSG00000196684 and 84941, HSH2D and IDBG-642330 and ENSBTAG00000038154 and 100848273, Hsh2d and IDBG-167646 and ENSMUSG00000062007 and 209488, nuclei, protein binding, this GO :0002903 and negative regulation of B cell apoptotic process and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0009967 and positive regulation of signal transduction and biological process this GO :0042110 and T cell activation and biological process this GO :0051902 and negative regulation of mitochondrial depolarization and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, hematopoietic SH2 domain containing |
| Identity: |
24920 |
| Gene: |
HSH2D |
More about : HSH2D |
| Long gene name: |
hematopoietic SH2 domain containing |
| Locus: |
19p13, 11 |
| Discovery year: |
2004-03-31 |
| GenBank acession: |
AK027792 |
| Entrez gene record: |
84941 |
| Pubmed identfication: |
11700021 |
| RefSeq identity: |
NM_032855 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182256 |