| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DIP13B/APPL2 |
| Specificity: |
This antibody reacts specifically with DIP13B/APPL2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DIP13B/APPL2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
(DIP13â, (DIP13&, APPL, APPL1, APPL1 and APPL2 associate with NuRD/MeCP1 and are essential for cell growth and proliferation, APPL2 also associates with follicle stimulating hormone receptor (FSHR), APPL2 is highly expressed in heart, APPL2 shares 54% homology with APPL1, In the nucleus, PTB domain and leucine zipper motif 1, PTB domain and leucine zipper motif 2 or DCC interacting protein 13â, They associate with GTPase Rab 5 and are released from the plasma membrane and translocated to the nucleus, also designated adaptor protein containing pH domain, also designated adaptor protein containing pH domain, and APPL2, and kidney, are involved in the coupling of epidermal growth factor (EGF) signaling and chromatin remodeling in the nucleus, brain, or DCC interacting protein 13&, skeletal muscle, trafficking and signaling downstream of tyrosine kinase receptors, &circ, &circ, «, «, ), ), The APPL family of proteins are involved in linking, aring, aring |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ10659 DIP13B |
| Also known as: |
DIP13B/APPL2 Polyclonal Antibody |
| Other name: |
Anti-DIP13B/APPL2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DIP13B/APPL2 |
| Short name: |
Anti-DIP13B/APPL2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-DIP13B/APPL2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18242 |
| Gene: |
APPL2 |
More about : APPL2 |
| Long gene name: |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
| Synonyms gene name: |
PH domain and leucine zipper containing 2 , adaptor protein, phosphotyrosine interaction |
| Synonyms name: |
DCC-interacting protein 13-beta |
| Locus: |
12q23, 3 |
| Discovery year: |
2007-01-26 |
| GenBank acession: |
AY113704 |
| Entrez gene record: |
55198 |
| Pubmed identfication: |
11431708 17030088 |
| RefSeq identity: |
NM_018171 |
| Classification: |
Pleckstrin homology domain containing BAR-PH domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000169853 |