| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TANK |
| Specificity: |
This antibody reacts specifically with TANK |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TANK |
| Gene ID: |
10010 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
For example, Specifically, TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, and inhibit LMP1-mediated NF kappa B activation, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB, or TRAF3, the Epstein Barr virus transforming protein, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm, this protein can block TRAF2 binding to LMP1, TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
I-TRAF |
| Also known as: |
TANK Polyclonal Antibody |
| Other name: |
Anti-TANK Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TANK |
| Short name: |
Anti-TANK (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TANK (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11562 |
| Gene: |
TANK |
More about : TANK |
| Long gene name: |
TRAF family member associated NFKB activator |
| Synonyms gene: |
TRAF2 |
| Synonyms gene name: |
TRAF family member-associated NFKB activator |
| Locus: |
2q24, 2 |
| Discovery year: |
1997-06-12 |
| GenBank acession: |
U59863 |
| Entrez gene record: |
10010 |
| Pubmed identfication: |
8710854 8855313 |
| RefSeq identity: |
NM_133484 |
| Havana BLAST/BLAT: |
OTTHUMG00000132037 |