| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Guanylyl Cyclase alpha 1 |
| Specificity: |
This antibody reacts specifically with Guanylyl Cyclase alpha 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 1 |
| Gene ID: |
2982 |
| Swiss Prot: |
Q02108 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, Both the alpha and beta subunits are required for cGMP generation, GCS, GCS is a heme containing heterodimer, Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, It plays a crucial role in smooth muscle contractility, The heme moeity mediates NO activation, The membrane-bound receptor forms, The soluble forms, There are two forms of guanylate cyclase, YC-1, YC-1 can also stimulate GCS in a NO-independent manner, a cGMP-synthesizing enzyme, act as receptors for nitric oxide, and at least two isoforms exist for each subunit, and both display similar enzymatic activity, and one beta subunit, and this heme group also binds carbon monoxide, are peptide hormone receptors, consisting of one alpha subunit, designated GCS-alpha-1, is the major receptor for the neurotransmitter nitric oxide (NO), known as GC, known as GCS or sGC, platelet reactivity and neurotransmission, which weakly stimulates the enzyme, Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GC-SA3, GCS-alpha-1, GCS-alpha-3, GUC1A3, GUCSA3, GUCY1A1, GUCY1A3, Guanylate cyclase soluble subunit alpha-3, MYMY6, Soluble guanylate cyclase large subunit, GUCA3 |
| Also known as: |
Guanylyl Cyclase alpha 1 Antibody |
| Other name: |
Anti-Guanylyl Cyclase alpha 1 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Guanylyl Cyclase alpha 1 |
| Short name: |
Fluor 594, Anti-Guanylyl Cyclase alpha 1 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Guanylyl Cyclase a 1 |