| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Fukutin |
| Specificity: |
This antibody reacts specifically with Fukutin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Fukutin |
| Gene ID: |
282969 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
FCMD is the first human disease known to be caused by an ancient retrotransposal integration, Fukutin colocalizes with a Golgi marker and a granular cytoplasmic distribution, Fukutin deficiency affects the modification of glycosylation of DAG1 (Î, Fukutin may be located in the extracellular matrix, The fukutin gene is expressed at similar levels in control fetal and adult brain, The gene which encodes fukutin maps to human chromosome 9q31, a secreted protein, alternatively, as a secreted protein, but is much reduced in Fukuyama congenital muscular dystrophy (FCMD) brains, fukutin may cause muscular dystrophy by an unknown mechanism, is expressed in various tissues in normal individuals, suggesting that fukutin passes through the Golgi before being packaged into secretory vesicles, where it interacts with and reinforces a large complex encompassing the outside and inside of muscle membranes, which then cannot localize or function properly and may be degraded or eluted from the extracellular surface membrane of the muscle fiber, ±, -dystroglycan), Fukutin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
LGMD2I MDC1C |
| Also known as: |
Fukutin Polyclonal Antibody |
| Other name: |
Anti-Fukutin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Fukutin |
| Short name: |
Anti-Fukutin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Fukutin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17997 |
| Gene: |
FKRP |
More about : FKRP |
| Long gene name: |
fukutin related protein |
| Locus: |
19q13, 32 |
| Discovery year: |
2003-12-04 |
| GenBank acession: |
AJ314847 |
| Entrez gene record: |
79147 |
| Pubmed identfication: |
11592034 11741828 |
| RefSeq identity: |
NM_024301 |
| Havana BLAST/BLAT: |
OTTHUMG00000183177 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy Pages Leiden Muscular Dystrophy pages LRG_761 |