| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FOXO4 Thr451 |
| Specificity: |
This antibody reacts specifically with FOXO4 (Thr451) |
| Modification: |
Phosphorylation |
| Modification site: |
Thr451 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human FOXO4 around the phosphorylation site of Thr451 |
| Gene ID: |
4303 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes, It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1, It is also involved in negative regulation of the cell cycle, FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AFX1 |
| Also known as: |
FOXO4 (Thr451) Polyclonal Antibody |
| Other name: |
Anti-FOXO4 (Thr451) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FOXO4 (Thr451) |
| Short name: |
Anti-FOXO4 (Thr451) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FOXO4 (Thr451) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7139 |
| Gene: |
FOXO4 |
More about : FOXO4 |
| Long gene name: |
forkhead box O4 |
| Synonyms gene: |
MLLT7 |
| Synonyms gene name: |
7 , 7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog), translocated to, translocated to |
| Locus: |
Xq13, 1 |
| Discovery year: |
1994-12-14 |
| Entrez gene record: |
4303 |
| Pubmed identfication: |
7529552 |
| RefSeq identity: |
NM_005938 |
| Classification: |
Forkhead boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000021789 |
| Locus Specific Databases: |
Mental Retardation database |