| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FANCC |
| Specificity: |
This antibody reacts specifically with FANCC |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FANCC |
| Gene ID: |
2176 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4, Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, FANCC is expressed in a cell cycle-dependent manner, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8), In addition, In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7, The FA Group C complementation group gene encodes the protein FANCC, The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3), These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8), birth defects and chromsomal instability (1, which is a transcriptional repressor (6), which is located in both cytoplasmic and nuclear compartments, which suggests that FANCC indirectly suppresses the activity of PKR, with the lowest levels at the G1/S boundary and the highest levels in the M-phase, 2), 5), 8), Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FAC FA3 |
| Also known as: |
FANCC Polyclonal Antibody |
| Other name: |
Anti-FANCC Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FANCC |
| Short name: |
Anti-FANCC (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, complementation family C (polyclonal), antibody to-Fanconi anemia |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
FA3 and FAC and FACC, FANCC and IDBG-636496 and ENSBTAG00000017195 and 281762, FANCC and IDBG-77041 and ENSG00000158169 and 2176, Fancc and IDBG-160833 and ENSMUSG00000021461 and 14088, complementation group C, nuclei, protein binding, this GO :0002262 and myeloid cell homeostasis and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006461 and protein complex assembly and biological process this GO :0007276 and gamete generation and biological process this GO :0007281 and germ cell development and biological process this GO :0019430 and removal of superoxide radicals and biological process this GO :0043240 and Fanconi anaemia nuclear complex and cellular component this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, Fanconi anemia |
| Identity: |
3584 |
| Gene: |
FANCC |
More about : FANCC |
| Long gene name: |
Fanconi anemia complementation group C |
| Synonyms gene: |
FACC |
| Locus: |
9q22, 32 |
| Discovery year: |
1992-11-25 |
| GenBank acession: |
BC006303 |
| Entrez gene record: |
2176 |
| Pubmed identfication: |
1303234 |
| RefSeq identity: |
NM_000136 |
| Classification: |
Fanconi anemia complementation groups |
| Havana BLAST/BLAT: |
OTTHUMG00000020279 |
| Locus Specific Databases: |
Fanconi Anaemia Mutation Database Fanconi anemia database LRG_497 |