| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
alpha B Crystallin Ser45 |
| Specificity: |
This antibody reacts specifically with alpha B Crystallin (Ser45) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser45 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser45 |
| Gene ID: |
1410 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alpha and beta families are further divided into acidic and basic groups, Alpha crystallins are composed of two gene products: alpha-A and alpha-B, Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family, Alpha-A and alpha-B gene products are differentially expressed, Elevated expression of alpha-B crystallin occurs in many neurological diseases, Jul 2008], Mammalian lens crystallins are divided into alpha, Post-translational modifications decrease the ability to chaperone, Seven protein regions exist in crystallins: four homologous motifs, Since lens central fiber cells lose their nuclei during development, The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens, These heterogeneous aggregates consist of 30-40 subunits, They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture, [provided by RefSeq, a connecting peptide, a missense mutation cosegregated in a family with a desmin-related myopathy, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs, and N- and C-terminal extensions, and gamma families, and ubiquitous, beta, beta and gamma crystallins are also considered as a superfamily, for acidic and basic, instead they hold them in large soluble aggregates, making them extremely stable proteins, or enzyme, respectively, respectively, the alpha-A and alpha-B subunits have a 3:1 ratio, these crystallins are made and then retained throughout life, Crystallins are separated into two classes: taxon-specific |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AACRYA, Alpha B crystallin, Alpha crystallin B chain, Alpha crystallin B chain, Alpha-crystallin B chain, AlphaB crystallin, AlphaB-crystallin, CRYA2, CRYAB, CRYAB_HUMAN, CTPP 2, CTPP2, Crystallin alpha B, Crystallin alpha polypeptide 2, HSPB5, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, alpha B Crystallin phospho Ser45, p-alpha B Crystallin S45, p-alpha B Crystallin Ser45, alpha B Crystallin phospho S45 |
| Also known as: |
alpha B Crystallin (Ser45) Antibody |
| Other name: |
Anti-alpha B Crystallin (Ser45) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
alpha B Crystallin (Ser45) |
| Short name: |
Anti-alpha B Crystallin (Ser45) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-a B Crystallin (Ser45) |