| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GDF8/MSTN |
| Specificity: |
This antibody reacts specifically with GDF8/MSTN |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GDF8 |
| Gene ID: |
2660 |
| Swiss Prot: |
O14793 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts specifically as a negative regulator of skeletal muscle growth, Belongs to the TGF-beta family, The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues, This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth, This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues, Weak expression in adipose tissue, [SUBUNIT] Homodimer, [TISSUE SPECIFICITY] Expressed specifically in developing and adult skeletal muscle, The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
GDF8/MSTN Polyclonal Antibody |
| Other name: |
Anti-GDF8/MSTN Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GDF8/MSTN |
| Short name: |
Anti-GDF8/MSTN (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GDF8/myostatin (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DNA-templated and biological process this GO :0048632 and negative regulation of skeletal muscle tissue growth and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0071549 and cellular response to dexamethasone stimulus and biological process, Extracellular, GDF8 and MSLHP, MSTN and IDBG-639462 and ENSBTAG00000011808 and 281187, MSTN and IDBG-77438 and ENSG00000138379 and 2660, Mstn and IDBG-153903 and ENSMUSG00000026100 and 17700, identical protein binding, this GO :0005102 and receptor binding and molecular function this GO :0005125 and cytokine activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007517 and muscle organ development and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008201 and heparin binding and molecular function this GO :0009408 and response to heat and biological process this GO :0009629 and response to gravity and biological process this GO :0014732 and skeletal muscle atrophy and biological process this GO :0014741 and negative regulation of muscle hypertrophy and biological process this GO :0014850 and response to muscle activity and biological process this GO :0022602 and ovulation cycle process and biological process this GO :0033574 and response to testosterone and biological process this GO :0040007 and growth and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043403 and skeletal muscle tissue regeneration and biological process this GO :0043627 and response to estrogen and biological process this GO :0045471 and response to ethanol and biological process this GO :0045893 and positive regulation of transcription, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005125 : cytokine activity and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity and also this GO :0008201 : heparin binding and also this GO :0042802 : identical protein binding, this GO :0005125 : cytokine activity, this GO :0005515 : protein binding, this GO :0008083 : growth factor activity, this GO :0008201 : heparin binding, this GO :0042802 : identical protein binding, myostatin |
| Identity: |
4223 |
| Gene: |
MSTN |
More about : MSTN |
| Long gene name: |
myostatin |
| Synonyms gene: |
GDF8 |
| Synonyms gene name: |
growth differentiation factor 8 |
| Locus: |
2q32, 2 |
| Discovery year: |
1997-09-12 |
| GenBank acession: |
AF019627 |
| Entrez gene record: |
2660 |
| Pubmed identfication: |
9288100 10610713 17003236 |
| RefSeq identity: |
NM_005259 |
| Havana BLAST/BLAT: |
OTTHUMG00000132663 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy pages LRG_200 |