| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ASL/Argininosuccinate Lyase |
| Specificity: |
This antibody reacts specifically with ASL/Argininosuccinate Lyase |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ASL/Argininosuccinate Lyase |
| Gene ID: |
435 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ASL catalyzes the hydrolytic cleavage of argininosuccinic acid (ASA) to fumarate and arginine, ASL shares high sequence homology with the avian and reptilian eye lens protein, In addition, Localizing to the cytoplasm and existing as a homotetramer, Mutations in the gene encoding ASL leads to an accumulation of ASA in body fluids and results in Arginosuc-cinic aciduria (ASAuria), This reaction is also involved in the biosynthesis of arginine, an autosomal recessive disorder that is characterized by hyperammonemia, an essential step of the urea cycle which is crucial for the detoxification of ammonia, convulsions, d-crystallin, episodic unconsciousness and dry and brittle hair showing trich-orrhexis nodosa (weak points or nodes in the hair shaft), liver enlargement, physical and mental retardation, ASL is a member of the lyase 1 family of proteins and is predominantly expressed in the liver |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
ASL/Argininosuccinate Lyase Antibody |
| Other name: |
Anti-ASL/Argininosuccinate Lyase |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
ASL/Argininosuccinate Lyase |
| Short name: |
Fluor 594, Anti-ASL/Argininosuccinate Lyase |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ASL/Argininosuccinate Lyase |
| Identity: |
746 |
| Gene: |
ASL |
More about : ASL |
| Long gene name: |
argininosuccinate lyase |
| Locus: |
7q11, 21 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
435 |
| RefSeq identity: |
NM_000048 |
| Havana BLAST/BLAT: |
OTTHUMG00000022876 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |