| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BAMBI |
| Specificity: |
This antibody reacts specifically with BAMBI |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BAMBI |
| Gene ID: |
25805 |
| Swiss Prot: |
Q13145 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Pig/Swine (Sus scrofa), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain, BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines, BAMBI is expressed at high levels during odontogenesis, BAMBI transcription regulation is under the influence of beta-catenin, BMP, The BAMBI family of proteins are related to type I TGF-beta receptor family, however, smad3 and smad4, BAMBI is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NMA |
| Also known as: |
BAMBI Polyclonal Antibody |
| Other name: |
Anti-BAMBI Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BAMBI |
| Short name: |
Anti-BAMBI (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BAMBI and IDBG-638629 and ENSBTAG00000003045 and 530147, BAMBI and IDBG-66015 and ENSG00000095739 and 25805, Bambi and IDBG-127778 and ENSMUSG00000024232 and 68010, DNA-templated and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process, NMA, Plasma membranes, this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005109 and frizzled binding and molecular function this GO :0005114 and type II transforming growth factor beta receptor binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0010718 and positive regulation of epithelial to mesenchymal transition and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0032092 and positive regulation of protein binding and biological process this GO :0035413 and positive regulation of catenin import into nucleus and biological process this GO :0045893 and positive regulation of transcription, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005109 : frizzled binding and also this GO :0005114 : type II transforming growth factor beta receptor binding, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005109 : frizzled binding, this GO :0005114 : type II transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding, BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) |
| Identity: |
30251 |
| Gene: |
BAMBI |
More about : BAMBI |
| Long gene name: |
BMP and activin membrane bound inhibitor |
| Synonyms gene name: |
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) |
| Locus: |
10p12, 1 |
| Discovery year: |
2004-02-04 |
| GenBank acession: |
U23070 |
| Entrez gene record: |
25805 |
| Pubmed identfication: |
8621228 19758997 |
| RefSeq identity: |
NM_012342 |
| Havana BLAST/BLAT: |
OTTHUMG00000017874 |