| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MISRII/AMHR2 |
| Specificity: |
This antibody reacts specifically with MISRII/AMHR2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MISRII/AMHR2 |
| Gene ID: |
269 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2), MISR II also acts as a receptor for anti-Muellerian hormone, MISR II belongs to the protein kinase superfamily, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males, TGFB receptor subfamily and contains one protein kinase domain, TKL Ser/Thr protein kinase family, These type II receptors rylate and activate type I receptors which autophosphorylate, Upon ligand binding, then bind and activate Smad transcriptional regulators, MISR II is a 573 amino acid protein encoded by the human gene AMHR2 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MISR2 MISRII |
| Also known as: |
MISRII/AMHR2 Polyclonal Antibody |
| Other name: |
Anti-MISRII/AMHR2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MISRII/AMHR2 |
| Short name: |
Anti-MISRII/AMHR2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, classification II (polyclonal), antibody to-MISRII/antibody to-Mullerian hormone receptor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AMHR and MISR2 and MISRII and MRII, AMHR2 and IDBG-36672 and ENSG00000135409 and 269, AMHR2 and IDBG-631327 and ENSBTAG00000018524 and, Amhr2 and IDBG-188637 and ENSMUSG00000023047 and 110542, Plasma membranes, this GO :0001880 and Mullerian duct regression and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005026 and transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004872 : receptor activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005026 : transforming growth factor beta receptor activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004872 : receptor activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005026 : transforming growth factor beta receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042562 : hormone binding, this GO :0046872 : metal ion binding, this GO :1990272 : anti-Mullerian hormone receptor activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042562 : hormone binding and also this GO :0046872 : metal ion binding and also this GO :1990272 : anti-Mullerian hormone receptor activity, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0042562 and hormone binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :1902613 and negative regulation of anti-Mullerian hormone signaling pathway and biological process this GO :1990262 and anti-Mullerian hormone signaling pathway and biological process this GO :1990272 and anti-Mullerian hormone receptor activity and molecular function, transforming growth factor beta receptor activity, type II, type II, type II and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, type II and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007548 and sex differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, anti-Mullerian hormone receptor |
| Identity: |
465 |
| Gene: |
AMHR2 |
More about : AMHR2 |
| Long gene name: |
anti-Mullerian hormone receptor type 2 |
| Synonyms gene name: |
anti-Mullerian hormone receptor type II |
| Synonyms name: |
Muellerian inhibiting substance type II receptor |
| Locus: |
12q13, 13 |
| Discovery year: |
1997-07-22 |
| GenBank acession: |
AF172932 |
| Entrez gene record: |
269 |
| Pubmed identfication: |
7493017 |
| RefSeq identity: |
NM_020547 |
| Classification: |
Type 2 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000170048 |