| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TRAF2 |
| Specificity: |
This antibody reacts specifically with TRAF2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TRAF2 |
| Gene ID: |
7186 |
| Swiss Prot: |
Q12933 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, In complex with BIRC2 or BIRC3, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR, RIPK1 and TICAM1, Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, Required for normal antibody isotype switching from IgM to IgG, promotes ubiquitination of IKBKE, such as BIRC3, this does not depend on the TRAF2 RING-type zinc finger domain, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases, Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TRAP3 |
| Also known as: |
TRAF2 Polyclonal Antibody |
| Other name: |
Anti- TRAF2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TRAF2 |
| Short name: |
Anti- TRAF2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, Antibody to tumor necrosis factor receptor-associated factor 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
MGC:45012 and TRAP and TRAP3, Plasma membranes, TRAF2 and IDBG-641438 and ENSBTAG00000010497 and 512355, TRAF2 and IDBG-92817 and ENSG00000127191 and 7186, Traf2 and IDBG-146254 and ENSMUSG00000026942 and 22030, metal ion binding, this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005174 and CD40 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0016874 and ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0030163 and protein catabolic process and biological process this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031996 and thioesterase binding and molecular function this GO :0032403 and protein complex binding and molecular function this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034351 and negative regulation of glial cell apoptotic process and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0043623 and cellular protein complex assembly and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0046328 and regulation of JNK cascade and biological process this GO :0046625 and sphin this GO lipid binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051023 and regulation of immunoglobulin secretion and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070207 and protein homotrimerization and biological process this GO :0070534 and protein K63-linked ubiquitination and biological process this GO :0071732 and cellular response to nitric oxide and biological process this GO :0090073 and positive regulation of protein homodimerization activity and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097300 and programmed necrotic cell death and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0004871 : signal transducer activity and also this GO :0005102 : receptor binding and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005174 : CD40 receptor binding and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity and also this GO :0019899 : enzyme binding and also this GO :0019903 : protein phosphatase binding and also this GO :0031435 : mitogen-activated protein kinase kinase kinase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0031996 : thioesterase binding and also this GO :0032403 : protein complex binding and also this GO :0042802 : identical protein binding and also this GO :0046625 : sphin this GO lipid binding and also this GO :0046872 : metal ion binding, this GO :0004871 : signal transducer activity, this GO :0005102 : receptor binding, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005174 : CD40 receptor binding, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, this GO :0019899 : enzyme binding, this GO :0019903 : protein phosphatase binding, this GO :0031435 : mitogen-activated protein kinase kinase kinase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0031996 : thioesterase binding, this GO :0032403 : protein complex binding, this GO :0042802 : identical protein binding, this GO :0046625 : sphin this GO lipid binding, this GO :0046872 : metal ion binding, TNF receptor-associated factor 2 |
| Identity: |
12032 |
| Gene: |
TRAF2 |
More about : TRAF2 |
| Long gene name: |
TNF receptor associated factor 2 |
| Locus: |
9q34, 3 |
| Discovery year: |
1999-04-28 |
| GenBank acession: |
U12597 |
| Entrez gene record: |
7186 |
| Pubmed identfication: |
7639698 |
| RefSeq identity: |
NM_021138 |
| Classification: |
Ring finger proteins TNF receptor associated factors |
| Havana BLAST/BLAT: |
OTTHUMG00000020952 |