| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SLC6A7/PROT |
| Specificity: |
This antibody reacts specifically with SLC6A7/PROT |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SLC6A7/PROT |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Enriched in glutamatergic synaptic terminals, LP-403812 and Des-Tyr-Leu-enkephalin (GGFL), PROT (Sodium-dependent proline transporter), PROT terminates the action of proline by its high affinity sodium/chloride-dependent reuptake into pre-synaptic terminals, PROT-mediated proline uptake is inhibited by compounds such as benztropine, These inhibitors of proline uptake may lead to the development of therapeutic agents for certain neurologic disorders, also known as Solute carrier family 6 member 7, is a 636 amino acid multi-pass membrane protein that is a GAT1 family member specifically expressed in regions of the brain, it is likely that PROT plays an important role in excitatory events of neurotransmission, metabolites and osmolites, which couple substrate flux to transmembrane electrochemical gradients, The GAT1 gene family includes sodium- and chloride-dependent plasma membrane transporters for neurotransmitters |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PROT |
| Also known as: |
SLC6A7/PROT Polyclonal Antibody |
| Other name: |
Anti-SLC6A7/PROT Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SLC6A7/PROT |
| Short name: |
Anti-SLC6A7/PROT (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SLC6A7/PROT (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11054 |
| Gene: |
SLC6A7 |
More about : SLC6A7 |
| Long gene name: |
solute carrier family 6 member 7 |
| Synonyms gene name: |
L-proline), member 7 , member 7 solute carrier family 6 (neurotransmitter transporter), solute carrier family 6 (neurotransmitter transporter |
| Synonyms name: |
brain-specific L-proline transporter sodium-dependent proline transporter |
| Locus: |
5q32 |
| Discovery year: |
1994-03-16 |
| GenBank acession: |
S80071 |
| Entrez gene record: |
6534 |
| Pubmed identfication: |
7651355 |
| RefSeq identity: |
NM_014228 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000130046 |