| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
², 4, CACNB4/L-type Ca++ CPÎ |
| Specificity: |
², 4, This antibody reacts specifically with CACNB4/L-type Ca++ CPÎ |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
², 4, KLH conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPÎ |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CACNLB4 or CAB4, Functioning as one of the four components of the Beta subunit, L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, L-type Ca++ CP Beta 4, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, The Beta subunit is encoded by four genes, Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), brain and smooth muscle, designated Beta1-Beta 4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting, Voltage-dependent calcium channels are essential for the release of neurotransmitters |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
EJM4 |
| Also known as: |
², 4 Antibody, CACNB4/L-type Ca++ CPÎ |
| Other name: |
², 4, Anti-CACNB4/L-type Ca++ CPÎ |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
², 4, CACNB4/L Ca++ CPÎ |
| Short name: |
Fluor 594, ², 4, Anti-CACNB4/L-type Ca++ CPÎ |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, b 4 subunit/L-classification Ca+and CPÎ, voltage-dependent, ², 4, antibody to-calcium channel |
| Alternative to gene target: |
CAB4 and CACNLB4 and EA5 and EIG9 and EJM and EJM4 and EJM6, CACNB4 and IDBG-641796 and ENSBTAG00000002297 and 282161, CACNB4 and IDBG-72371 and ENSG00000182389 and 785, Cacnb4 and IDBG-170902 and ENSMUSG00000017412 and 12298, Plasma membranes, beta 4 subunit, glutamatergic and biological process this GO :0042391 and regulation of membrane potential and biological process this GO :0045202 and synapse and cellular component this GO :0046058 and cAMP metabolic process and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0048541 and Peyer's patch development and biological process this GO :0048747 and muscle fiber development and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050877 and neurological system process and biological process this GO :0050908 and detection of light stimulus involved in visual perception and biological process this GO :0051899 and membrane depolarization and biological process this GO :0070588 and calcium ion transmembrane transport and biological process this GO :1901385 and regulation of voltage-gated calcium channel activity and biological process, protein kinase binding, this GO :0005245 and voltage-gated calcium channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005891 and voltage-gated calcium channel complex and cellular component this GO :0006810 and transport and biological process this GO :0006816 and calcium ion transport and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0007214 and gamma-aminobutyric acid signaling pathway and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007411 and axon guidance and biological process this GO :0007528 and neuromuscular junction development and biological process this GO :0007628 and adult walking behavior and biological process this GO :0008331 and high voltage-gated calcium channel activity and molecular function this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0014051 and gamma-aminobutyric acid secretion and biological process this GO :0019227 and neuronal action potential propagation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0035249 and synaptic transmission, this GO :0005245 : voltage-gated calcium channel activity, this GO :0005245 : voltage-gated calcium channel activity and also this GO :0005515 : protein binding and also this GO :0008331 : high voltage-gated calcium channel activity and also this GO :0019901 : protein kinase binding, this GO :0005515 : protein binding, this GO :0008331 : high voltage-gated calcium channel activity, this GO :0019901 : protein kinase binding, voltage-dependent, calcium channel |
| Identity: |
1404 |
| Gene: |
CACNB4 |
More about : CACNB4 |
| Long gene name: |
calcium voltage-gated channel auxiliary subunit beta 4 |
| Synonyms gene name: |
beta 4 subunit , calcium channel, voltage-dependent |
| Locus: |
2q23, 3 |
| Discovery year: |
1997-04-21 |
| GenBank acession: |
AF038852 |
| Entrez gene record: |
785 |
| Pubmed identfication: |
9628818 |
| RefSeq identity: |
NM_000726, 3 |
| Classification: |
Calcium voltage-gated channel subunits Membrane associated guanylate kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000155091 |