| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SPOCK1/Testican 1 |
| Specificity: |
This antibody reacts specifically with SPOCK1/Testican 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SPOCK1/Testican 1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
After a neural injury, Expression of Testicans is detected in a variety of tissues, Family members include Testican-1, Most Testicans inhibit MT-MMPs, Testican-1 expression is upregulated in astrocyte cells in order to inhibit the ability of the protein Neuro-2a to form neurite extensions, Testican-1 is also a component of joint and of the growth plate cartilage that may participate in the regulation of matrix turnover, Testican-1 is specifically expressed in the thalamus of the brain, Testican-2, Testican-3 and an amino-terminal splice variant of Testican-3, also designated the BM-40/SPARC/osteonectin family, and is upregulated in activated astroglial cells of the cerebrum where it mediates neuronal attachment and matrix metalloproteinase activation, but is most abundant in brain, calcium-binding, designated N-Tes, extracellular, is composed of highly conserved, such as a cerebral stroke, sulfate proteoglycans, thereby inhibiting the activity of pro-MMP-2, The Testican family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
testican-1 |
| Also known as: |
SPOCK1/Testican 1 Polyclonal Antibody |
| Other name: |
Anti-SPOCK1/Testican 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SPOCK1/Testican 1 |
| Short name: |
Anti-SPOCK1/Testican 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, acidic, cwcv and kazal-like domains proteoglycan (testican) 1/Testican 1 (polyclonal), cysteine-rich (osteonectin)/osteonectin, antibody to-secreted protein |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Extracellular, SPOCK and TESTICAN and TIC1, SPOCK1 and IDBG-46103 and ENSG00000152377 and 6695, SPOCK1 and IDBG-645860 and ENSBTAG00000003502 and 511211, Spock1 and IDBG-157690 and ENSMUSG00000056222 and 20745, cwcv and kazal-like domains proteoglycan (testican) 1, metalloendopeptidase inhibitor activity, this GO :0001558 and regulation of cell growth and biological process this GO :0001764 and neuron migration and biological process this GO :0004867 and serine-type endopeptidase inhibitor activity and molecular function this GO :0004869 and cysteine-type endopeptidase inhibitor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0008191 and metalloendopeptidase inhibitor activity and molecular function this GO :0010812 and negative regulation of cell-substrate adhesion and biological process this GO :0010951 and negative regulation of endopeptidase activity and biological process this GO :0010977 and negative regulation of neuron projection development and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0016528 and sarcoplasm and cellular component this GO :0021953 and central nervous system neuron differentiation and biological process this GO :0022008 and neurogenesis and biological process this GO :0031594 and neuromuscular junction and cellular component this GO :0033268 and node of Ranvier and cellular component, this GO :0004867 : serine-type endopeptidase inhibitor activity, this GO :0004867 : serine-type endopeptidase inhibitor activity and also this GO :0004869 : cysteine-type endopeptidase inhibitor activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0008191 : metalloendopeptidase inhibitor activity, this GO :0004869 : cysteine-type endopeptidase inhibitor activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0008191 : metalloendopeptidase inhibitor activity, sparc/osteonectin |
| Identity: |
11251 |
| Gene: |
SPOCK1 |
More about : SPOCK1 |
| Long gene name: |
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1 |
| Synonyms gene: |
TIC1 SPOCK |
| Synonyms gene name: |
cwcv and kazal-like domains proteoglycan (testican) , sparc/osteonectin |
| Locus: |
5q31, 2 |
| Discovery year: |
1995-10-02 |
| GenBank acession: |
AF231124 |
| Entrez gene record: |
6695 |
| Pubmed identfication: |
9545645 |
| RefSeq identity: |
NM_004598 |
| Classification: |
SPARC family |
| Havana BLAST/BLAT: |
OTTHUMG00000129157 |