| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SNAIL + SLUG Ser246 |
| Specificity: |
This antibody reacts specifically with SNAIL + SLUG(Ser246) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser246 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human SNAIL around the phosphorylation site of Ser246 |
| Gene ID: |
6311 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Mutations in this gene may be associated with sporadic cases of neural tube defects (referenced from Entrez gene), SLUG also has antiapoptotic activity, SLUG is involved in epithelial-mesenchymal transitions (EMT) involving E-cadherin repression which is known to play an important role in tumor progression amd neural tube formation, The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin, This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SNA SLUGH2 SNAH SNAIL1 SNAIL |
| Also known as: |
SNAIL + SLUG(Ser246) Polyclonal Antibody |
| Other name: |
Anti-SNAIL + SLUG(Ser246) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SNAIL + SLUG(Ser246) |
| Short name: |
Anti-SNAIL + SLUG(Ser246) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SNAIL and SLUG(Ser246) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11128 |
| Gene: |
SNAI1 |
More about : SNAI1 |
| Long gene name: |
snail family transcriptional repressor 1 |
| Synonyms gene name: |
snail 1 (drosophila homolog), zinc finger protein snail homolog 1 (Drosophila) snail family zinc finger 1 |
| Locus: |
20q13, 13 |
| Discovery year: |
1998-07-03 |
| GenBank acession: |
AF125377 |
| Entrez gene record: |
6615 |
| Pubmed identfication: |
10585766 |
| Classification: |
Zinc fingers C2H2-type SNAG transcriptional repressors |
| Havana BLAST/BLAT: |
OTTHUMG00000033048 |