| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SLC25A12/ARALAR |
| Specificity: |
This antibody reacts specifically with SLC25A12/ARALAR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ARALAR, ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle, ARALAR is implicated in conferring susceptibility to schizophrenia, ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation, In addition, It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH, Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS), the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Aralar |
| Also known as: |
SLC25A12/ARALAR Polyclonal Antibody |
| Other name: |
Anti-SLC25A12/ARALAR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SLC25A12/ARALAR |
| Short name: |
Anti-SLC25A12/ARALAR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SLC25A12/ARALAR (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10982 |
| Gene: |
SLC25A12 |
More about : SLC25A12 |
| Long gene name: |
solute carrier family 25 member 12 |
| Synonyms gene name: |
Aralar), member 12 , member 12 solute carrier family 25 (aspartate/glutamate carrier), solute carrier family 25 (mitochondrial carrier |
| Locus: |
2q31, 1 |
| Discovery year: |
1999-01-28 |
| GenBank acession: |
Y14494 |
| Entrez gene record: |
8604 |
| Pubmed identfication: |
9722566 10702666 11566871 |
| RefSeq identity: |
NM_003705 |
| Classification: |
Solute carriers EF-hand domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000134290 |