| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PHYHIP |
| Specificity: |
This antibody reacts specifically with PHYHIP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PHYHIP |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
In transgenic mice, PAHX, PHYHIP also interacts with Dyrk1A, PHYHIP interacts with the Refsum disease gene product, Significantly, a protein that that is overexpressed in brain of Down-syndrome patients, breast and several other types of cancers, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, neurologic damage and peripheral neuropathies, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia, small intestine and ovary, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome, which is characterized by cerebellar degeneration, with weak expression in ovary, PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0273 PAHX-AP |
| Also known as: |
PHYHIP Polyclonal Antibody |
| Other name: |
Anti-PHYHIP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PHYHIP |
| Short name: |
Anti-PHYHIP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PHYHIP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16865 |
| Gene: |
PHYHIP |
More about : PHYHIP |
| Long gene name: |
phytanoyl-CoA 2-hydroxylase interacting protein |
| Synonyms gene: |
DYRK1AP3 |
| Synonyms gene name: |
phytanoyl-CoA hydroxylase interacting protein DYRK1A interacting protein 3 |
| Locus: |
8p21, 3 |
| Discovery year: |
2001-11-16 |
| GenBank acession: |
D87463 |
| Entrez gene record: |
9796 |
| Pubmed identfication: |
9039502 10686344 |
| RefSeq identity: |
NM_014759 |
| Havana BLAST/BLAT: |
OTTHUMG00000163776 |