| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KALRN/Duo |
| Specificity: |
This antibody reacts specifically with KALRN/Duo |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human KALRN/Duo |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Duo, HAP1 is primarily expressed in brain tissue, HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4, Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, Mouse HAP1 is localized to membrane-bound organelles including large endosomes, The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1), also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function, the gene encodes a version of huntingtin that leads to Huntingtonâ, tubulovesicular structures and budding vesicles in neurons (6), with greater expression in the olfactory bulb and brain stem (1), &euro, &trade, 3), 5), HAP1 (huntingtin-associated protein 1) binds to huntingtin (1), s disease (HD) (2 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
duo Hs, 8004 TRAD DUET Kalirin ARHGEF24 |
| Also known as: |
KALRN/Duo Polyclonal Antibody |
| Other name: |
Anti-KALRN/Duo Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KALRN/Duo |
| Short name: |
Anti-KALRN/Duo (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, RhoGEF kinase/Duo (polyclonal), antibody to-kalirin |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ARHGEF24 and CHD5 and CHDS5 and DUET and DUO and HAPIP and TRAD, Cytoplasm, KALRN and IDBG-53661 and ENSG00000160145 and 8997, KALRN and IDBG-633466 and ENSBTAG00000002640 and 540675, Kalrn and IDBG-155984 and ENSMUSG00000061751 and 545156, RhoGEF kinase, this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046872 : metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, kalirin |
| Identity: |
4814 |
| Gene: |
KALRN |
More about : KALRN |
| Long gene name: |
RhoGEF kinase , kalirin |
| Synonyms gene: |
HAPIP |
| Synonyms gene name: |
huntingtin-associated protein interacting protein (duo) |
| Synonyms name: |
serine/threonine kinase with Dbl and pleckstrin homology domains |
| Locus: |
3q21, 1-q21, 2 |
| Discovery year: |
1999-01-13 |
| GenBank acession: |
U94190 |
| Entrez gene record: |
8997 |
| Pubmed identfication: |
9285789 10023074 |
| RefSeq identity: |
NM_003947 |
| Classification: |
Rho guanine nucleotide exchange factors I-set domain containing Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000125545 |