| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DYRK1A |
| Specificity: |
This antibody reacts specifically with DYRK1A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DYRK1A |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Dyrk family members, Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, Dyrk1A, Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, Four isoforms of Dyrk1A exist due to alternative splicing events, Localized to the nucleus and highly expressed in testis, Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases, also known as MNB or MNBH, are thought to be involved in diverse cellular functions, functions to phosphorylate serine, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), muscle and the developing nervous system, suggesting a possible role for Dyrk1A in the development of DS, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation, which is itself regulated by tyrosine phosphorylation, Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
DYRK1A Polyclonal Antibody |
| Other name: |
Anti-DYRK1A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DYRK1A |
| Short name: |
Anti-DYRK1A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-DYRK1A (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3091 |
| Gene: |
DYRK1A |
More about : DYRK1A |
| Long gene name: |
dual specificity tyrosine phosphorylation regulated kinase 1A |
| Synonyms gene: |
DYRK1 DYRK MNBH |
| Synonyms gene name: |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Locus: |
21q22, 13 |
| Discovery year: |
1999-01-29 |
| GenBank acession: |
U52373 |
| Entrez gene record: |
1859 |
| Pubmed identfication: |
9284911 |
| RefSeq identity: |
NM_001396 |
| Havana BLAST/BLAT: |
OTTHUMG00000086657 |