| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
OA1/GPR143 |
| Specificity: |
This antibody reacts specifically with OA1/GPR143 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human OA1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in the gene encoding for OA1 cause ocular albinism, G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation), GPR143, OA1, They respond to a great variety of signaling molecules, also designated ocular albinism type 1 protein (OA1), an X-linked disorder mainly characterized by retinal hypopigmentation and visual impairment, are members of the largest protein family and play a role in many different stimulus-response pathways, including hormones, is a melanosomal protein expressed primarily in pigment cells, is detected exclusively in pigment cells, neurotransmitters and other proteins and peptides, which is a multi-pass membrane protein, G protein-coupled receptors (GPRs or GPCRs) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
OA1/GPR143 Polyclonal Antibody |
| Other name: |
Anti-OA1/GPR143 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
OA1/GPR143 |
| Short name: |
Anti-OA1/GPR143 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-OA1/GPR143 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
20145 |
| Gene: |
GPR143 |
More about : GPR143 |
| Long gene name: |
G protein-coupled receptor 143 |
| Synonyms gene: |
OA1 |
| Synonyms gene name: |
ocular albinism 1 (Nettleship-Falls) |
| Synonyms name: |
ocular albinism 1 |
| Locus: |
Xp22, 2 |
| Discovery year: |
2003-12-01 |
| GenBank acession: |
Z48804 |
| Entrez gene record: |
4935 |
| Pubmed identfication: |
7647783 10471510 |
| RefSeq identity: |
NM_000273 |
| Classification: |
7TM orphan receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000021118 |
| Locus Specific Databases: |
Albinism Database Mutations of the OA1 Gene |