| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PON3 |
| Specificity: |
This antibody reacts specifically with PON3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PON3 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
In contrast to PON1, It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion, PON2 is expressed in a variety of mouse tissues, PON3 is a associated with the high density lipoprotein fraction of serum, PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, Parathion is inert until transformed to paroxon, Paroxonase or PON is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol, The genes which encode PON1-3 are physically linked and map to human chromosome 7q21, including the pancreas, inhibition properties and physicochemical characteristics such as electrophoretic mobility and molecular weight, used topically in the treatment of glaucoma, which is expressed mainly in the liver, 3, Paroxon is an organophosphorus anticholinesterase compound |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
PON3 Polyclonal Antibody |
| Other name: |
Anti-PON3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PON3 |
| Short name: |
Anti-PON3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PON3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9206 |
| Gene: |
PON3 |
More about : PON3 |
| Long gene name: |
paraoxonase 3 |
| Synonyms name: |
arylesterase 3 |
| Locus: |
7q21, 3 |
| Discovery year: |
1995-05-25 |
| GenBank acession: |
L48516 AF320003 |
| Entrez gene record: |
5446 |
| Pubmed identfication: |
8661009 |
| RefSeq identity: |
NM_000940 |
| Classification: |
Paraoxonases |
| Havana BLAST/BLAT: |
OTTHUMG00000153917 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |