| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ELAVL2 + ELAVL4 |
| Specificity: |
This antibody reacts specifically with ELAVL2 + ELAVL4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ELAVL2 |
| Gene ID: |
1993, 1996 |
| Swiss Prot: |
P25378, Q12926 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation, An additional mammalian homolog, Characteristically, Elav, Elav proteins function within the nucleus, HuD and Hel-N1, HuR, Several mammalian Elav-like proteins, When Elav-like proteins associate with these ARE sites this degradation is inhibited, a Drosophila protein and the first described member, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, are also expressed in postmitotic neurons, designated HuC, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance, is ubiquitously expressed and is also overexpressed in a wide variety of tumors, leading to an increased stability of the corresponding transcript, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites, which is also designated HuA, The Elav-like genes encode for a family of RNA-binding proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PNEM |
| Also known as: |
ELAVL2 + ELAVL4 Polyclonal Antibody |
| Other name: |
Anti-ELAVL2 + ELAVL4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ELAVL2 + ELAVL4 |
| Short name: |
Anti-ELAVL2 + ELAVL4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ELAVL2 and ELAVL4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3315 |
| Gene: |
ELAVL4 |
More about : ELAVL4 |
| Long gene name: |
ELAV like RNA binding protein 4 |
| Synonyms gene: |
HUD |
| Synonyms gene name: |
Drosophila)-like 4 (Hu antigen D) ELAV (embryonic lethal, Drosophila)-like 4 ELAV like neuron-specific RNA binding protein 4 , ELAV (embryonic lethal, abnormal vision, abnormal vision |
| Synonyms name: |
Hu antigen D |
| Locus: |
1p33-p32, 3 |
| Discovery year: |
1993-07-12 |
| GenBank acession: |
AY033998 |
| Entrez gene record: |
1996 |
| Pubmed identfication: |
8222755 |
| RefSeq identity: |
NM_021952 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000007877 |