| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FIG4/SAC3 |
| Specificity: |
This antibody reacts specifically with FIG4/SAC3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FIG4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration, Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), Unlike CMT4J, both of which negatively affect the nervous system, causing paralysis and, death, ultimately, FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SAC3 hSac3 dJ249I4, 1 ALS11 CMT4J |
| Also known as: |
FIG4/SAC3 Polyclonal Antibody |
| Other name: |
Anti-FIG4/SAC3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FIG4/SAC3 |
| Short name: |
Anti-FIG4/SAC3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FIG4/SAC3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16873 |
| Gene: |
FIG4 |
More about : FIG4 |
| Long gene name: |
FIG4 phosphoinositide 5-phosphatase |
| Synonyms gene: |
KIAA0274 |
| Synonyms gene name: |
KIAA0274 FIG4 homolog (S, SAC1 lipid phosphatase domain containing (S, cerevisiae) , cerevisiae) FIG4 homolog |
| Locus: |
6q21 |
| Discovery year: |
2003-11-26 |
| GenBank acession: |
D87464 |
| Entrez gene record: |
9896 |
| Pubmed identfication: |
9039502 11274189 17572665 |
| RefSeq identity: |
NM_014845 |
| Classification: |
Phosphoinositide phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000015352 |
| Locus Specific Databases: |
LRG_241 |