| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCR4 |
| Specificity: |
This antibody reacts specifically with CCR4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CCR-4 |
| Gene ID: |
1233 |
| Swiss Prot: |
P51679 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates, In the CNS, The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system, could mediate hippocampal-neuron survival, High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CCR4 KIAA1194 Ccr4a |
| Also known as: |
CCR4 Polyclonal Antibody |
| Other name: |
Anti-CCR4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCR4 |
| Short name: |
Anti-CCR4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-C motif) receptor 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C-C chemokine receptor activity, CC-CKR-4 and CD194 and ChemR13 and CKR4 and CMKBR4 and HGCN:14099 and K5-5, CCR4 and IDBG-23908 and ENSG00000183813 and 1233, CCR4 and IDBG-644121 and ENSBTAG00000034883 and 100851774, Ccr4 and IDBG-203512 and ENSMUSG00000047898 and 12773, Cell surfaces, this GO :0001764 and neuron migration and biological process this GO :0002507 and tolerance induction and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0009314 and response to radiation and biological process this GO :0009617 and response to bacterium and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016493 and C-C chemokine receptor activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0046677 and response to antibiotic and biological process this GO :0050927 and positive regulation of positive chemotaxis and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016493 : C-C chemokine receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0016493 : C-C chemokine receptor activity, 408019, chemokine (C-C motif) receptor 4 |
| Identity: |
14099 |
| Gene: |
CNOT6 |
More about : CNOT6 |
| Long gene name: |
CCR4-NOT transcription complex subunit 6 |
| Synonyms gene name: |
CCR4-NOT transcription complex, subunit 6 |
| Locus: |
5q35, 3 |
| Discovery year: |
2001-03-30 |
| GenBank acession: |
AB033020 |
| Entrez gene record: |
57472 |
| Pubmed identfication: |
11889047 |
| RefSeq identity: |
NM_015455 |
| Classification: |
CCR4-NOT transcription complex |
| Havana BLAST/BLAT: |
OTTHUMG00000130935 |