| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Aggrecan |
| Specificity: |
This antibody reacts specifically with Aggrecan |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from Human Aggrecan |
| Swiss Prot: |
P16112 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage, Aggrecan in cartilage forms aggregates with hyaluronan and link protein, Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification, Aggrecan is a member of the chondroitin sulphate proteoglycan family, Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family, In the adult brain, Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage, aggrecan, embedded in a collagen network, is the predominant proteoglycan present in cartilage, neurocan and brevican, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment, which also includes versican/PG-M, The large chondroitin sulfate proteoglycan |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CSPGCP ACAN |
| Also known as: |
Aggrecan Polyclonal Antibody |
| Other name: |
Anti-Aggrecan Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Aggrecan |
| Short name: |
Anti-Aggrecan (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Aggrecan (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7338 |
| Gene: |
MSK16 |
More about : MSK16 |
| Long gene name: |
aggrecan |
| Synonyms gene: |
CSPG1 AGC1 |
| Synonyms gene name: |
chondroitin sulfate proteoglycan 1 aggrecan 1 |
| Synonyms name: |
aggrecan proteoglycan |
| Locus: |
15q26, 1 |
| Discovery year: |
1992-06-17 |
| GenBank acession: |
M55172 |
| Entrez gene record: |
176 |
| Pubmed identfication: |
1985970 |
| RefSeq identity: |
NM_001135 |
| Classification: |
Sushi domain containing Hyalectan proteoglycans V-set domain containing C-type lectin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000171989 |