| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
LRRTM3 |
| Specificity: |
This antibody reacts specifically with LRRTM3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human LRRTM3 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All LRR repeats contain a variable segment and a highly conserved segment, As a result of alternative splicing events, Expressed in neuronal tissues, LRRTM family members are known to exhibit synaptogenic activity, LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid, LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, Localizing predominantly to the nervous system, The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development, allowing it to accommodate several leucine residues within a tightly packed core, and contains ten LRR repeats, the latter of which accounts for 11 or 12 residues of the entire LRR motif, two LRRTM3 isoforms exist, The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
LRRTM3 Polyclonal Antibody |
| Other name: |
Anti-LRRTM3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
LRRTM3 |
| Short name: |
Anti-LRRTM3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-LRRTM3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
19410 |
| Gene: |
LRRTM3 |
More about : LRRTM3 |
| Long gene name: |
leucine rich repeat transmembrane neuronal 3 |
| Locus: |
10q21, 3 |
| Discovery year: |
2004-02-04 |
| GenBank acession: |
BX640611 |
| Entrez gene record: |
347731 |
| Pubmed identfication: |
12676565 |
| RefSeq identity: |
NM_178011 |
| Havana BLAST/BLAT: |
OTTHUMG00000018332 |