| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KIBRA |
| Specificity: |
This antibody reacts specifically with KIBRA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human KIBRA |
| Gene ID: |
23286 |
| Swiss Prot: |
Q8IX03 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a substrate for PRKCZ, Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation, Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, Modulates directional migration of podocytes, Plays a role in cognition and memory performance, Regulates collagen-stimulated activation of the ERK/MAPK cascade, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis, Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIBRA KIAA0869 PPP1R168 |
| Also known as: |
KIBRA Polyclonal Antibody |
| Other name: |
Anti-KIBRA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KIBRA |
| Short name: |
Anti-KIBRA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-KIBRA (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
29435 |
| Gene: |
WWC1 |
More about : WWC1 |
| Long gene name: |
WW and C2 domain containing 1 |
| Synonyms gene name: |
C2 and coiled-coil domain containing 1 , WW |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 168 |
| Locus: |
5q34 |
| Discovery year: |
2006-02-22 |
| GenBank acession: |
AF506799 |
| Entrez gene record: |
23286 |
| Pubmed identfication: |
10048485 12559952 |
| RefSeq identity: |
NM_015238 |
| Classification: |
Protein phosphatase 1 regulatory subunits C2 and WW domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130408 |